Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4/NF-kB pathway.
RatEndotoxin/LPSSprague-Dawleyn = 48 rats randomised into six groups (per-group n not stated)Oral administration0.61, 1.22 and 2.44 g/kg (low, medium and high dose); posit…1 h before intraperitoneal LPS injection (pre-treatment)
Model: Lipopolysaccharide-induced acute lung injury; LPS 0.005 g/kg (E. coli 055:B5) by intraperitoneal injection
LQJD reduced the LPS-induced rise in body temperature, lowered serum TNF-alpha and IL-6, and reduced inflammatory infiltration and alveolar disruption on histology. TLR4 and NF-kBp65 were down-regulated at both mRNA and protein level in lung tissue.
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