Protective effects of tenuigenin on lipopolysaccharide and d-galactosamine-induced acute liver injury.
MouseChemical/toxinBALB/cIntraperitoneal1 h before LPS/D-galactosamine treatment (pre-treatment)
Model: Lipopolysaccharide plus D-galactosamine-induced acute liver injury
Tenuigenin significantly reduced LPS/D-galactosamine-induced serum ALT and AST, TNF-alpha and IL-1 beta, and hepatic MDA and MPO activity. It suppressed ASK1, NF-kB and MAPK activation while up-regulating Nrf2 and HO-1.
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