Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury.
RatCrushLimb / muscle crushWistar (specific pathogen free)Malen = Survival: n=6 sham, n=20 crush control and n=20 treated; bl…Intravenous via left external jugular vein catheter350 micrograms/kgImmediately before removal of the weights, that is at the end of the 6 h compre…
Model: Bilateral hindlimb crush injury: compression with a 3.0 kg apparatus for 6 h followed by release and reperfusion, with intravenous saline support at 1 ml/kg/h for the first 5 h and 10 ml/kg/h for the next 4 h
Survival within the first 24 h was 35% (7/20) in the crush control group and 80% (16/20) in the anti-RAGE treated group, and at 7 days was 10% (2/20) versus 50% (10/20) respectively (P<0.01). Anti-RAGE antibody suppressed lung RAGE expression at 3 and 6 h, lowered serum IL-6, sRAGE, sVCAM-1 and MMP…
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