Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9.
MouseOtherAfter ventilator-induced lung injury, in animals rendered neutropenic following…
Model: Ventilator-induced lung injury followed by induced neutropenia and 48 hours of spontaneous breathing; parallel human bronchoalveolar lavage fluid study in ventilated patients with acute respiratory distress syndrome
Neutropenic lungs showed delayed repair, higher TNF-alpha, interferon gamma and macrophage inflammatory protein 2, and absent MMP-9, mirrored in bronchoalveolar lavage fluid from neutropenic patients with acute respiratory distress syndrome. Treating neutropenic mice with exogenous MMP-9 after vent…
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