Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.

Model: Repetitive traumatic brain injury in mice, with in vitro scratch-injured neurons and BV2 microglia

miR-124-3p was the most increased miRNA in microglial exosomes after injury. It promoted M2 microglial polarisation, inhibited neuronal inflammation, promoted neurite outgrowth with reduced RhoA, amyloid-beta and phosphorylated tau, and improved neurological outcome and reduced neuroinflammation in…

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