EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.
MixedIschaemia-reperfusionCardiacWild-type, Emc10-deficient and bone marrow chimeric mice; heart failure-prone FVB/N mice used for recombinant protein therapyOsmotic minipump deliveryAfter myocardial infarction
Model: Myocardial infarction induced by transient coronary artery ligation
Emc10 knockout mice showed impaired infarct border zone capillarisation, larger infarct scars and more pronounced left ventricular remodelling than wild-type mice, and transplantation with wild-type bone marrow rescued the angiogenic defect. Treatment of FVB/N mice with recombinant Emc10 enhanced i…
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