The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury.
MixedOtherC57BL/6 (C57BL/6J)Malen = n = 8 to 9 mice per group for re-endothelialisation; n = 6…Oral gavage, dissolved in 40 per cent macrogol (15)-hydroxystearate and 10 per cent ethanol1 mg/kg/day or 10 mg/kg/day in vivo; 1 nM and 10 nM in vitr…Immediately before surgery, then once daily thereafter
Model: Electric denudation injury of the left common carotid artery (2 W for 2 seconds per millimetre over 4 mm) and wire-induced dilation injury of the femoral artery (0.38 mm straight spring wire advanced 1 cm and left in place for 1 minute)
Finerenone at 10 nM prevented aldosterone-induced smooth muscle cell proliferation and at 1 nM prevented endothelial cell apoptosis in vitro. In vivo, re-endothelialisation at day 3 increased from 0.52 plus or minus 0.12 mm with vehicle to 1.13 plus or minus 0.16 mm at 1 mg/kg/day and 1.083 plus or…
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