Ozone Partially Decreases Axonal and Myelin Damage in an Experimental Sciatic Nerve Injury Model.
RatCrushPeripheral-nerve crushSprague-DawleyMalen = 28 male rats, 7 per group across 4 groupsIntraperitoneal injection0.5 mg/kg at a concentration of 70 micrograms/mlFirst dose at the first hour after injury
Model: Acute sciatic nerve crush injury by compression of the right sciatic nerve for 90 seconds with a Yasargil aneurysm clip
Compound action potential amplitude and nerve conduction velocity were significantly higher, and myelin injury significantly lower, in ozone-treated injured rats than in untreated injured rats. Total oxidant status was significantly raised and total antioxidant status significantly lowered by injur…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.