The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
MouseTBIControlled cortical impactC57Bl/6 wild type and calpain-1 knockout on C57Bl/6 backgroundIntraperitoneal injectionNA101 0.3 mg/kg; nilotinib dose not stated1 h after traumatic brain injury
Model: Controlled cortical impact after 5 mm craniotomy, 3 mm impactor tip, impact velocity 3 m/s, cortical deformation depth 0.5 mm
NA101 given 1 h after controlled cortical impact largely prevented PTPN13 and spectrin truncation and the rise in c-Abl Tyr245 and tau tyrosine phosphorylation at 6 h, and both NA101 and nilotinib significantly reduced tau oligomer accumulation in ipsilateral cortex and hippocampus at 24 h. NA101 a…
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