Hydroalcoholic extract of Stevia rebaudiana bert. leaves and stevioside ameliorates lipopolysaccharide induced acute liver injury in rats.
RatEndotoxin/LPSWistarMaleOral (p.o.)STE EXT 500 mg/kg; stevioside 250 mg/kg
Model: Lipopolysaccharide-induced acute liver injury, LPS 5 mg/kg intraperitoneally
Both the leaf extract and stevioside reduced LPS-induced hepatic oxidative stress, normalised elevated serum and tissue AST and ALT, lowered TNF-alpha, IL-1beta and IL-6, and attenuated structural liver damage and hepatocellular apoptosis.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.