Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study.
RatTBIControlled cortical impactWistarMalen = 30 male Wistar rats: 6 h cell n=10, 1 week cell n=10, 6 h s…Intravenous, tail veinApproximately 3 x 10 to the power n hMSCs suspended in 1 ml…6 hours or 1 week after injury
Model: Controlled cortical impact to the left cortex, single impact at 4 m/s, 2.5 mm depth below dura, 6 mm diameter tip, after bilateral 10 mm craniotomies
Both cell-treated groups showed faster reduction of Ki and better spatial memory performance than saline. Acute (6 h) transplantation gave significantly lower Ki at 2 and 3 months and higher cerebral blood flow at 2 months versus saline, whereas delayed (1 week) treatment was less potent. Lesion vo…
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