Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
MouseWoundTopical application to the wound
Model: Cutaneous wound healing model in mice, including wounds in diabetic mice
GPNMB promoted recruitment of mesenchymal stem cells to injured skin, which modulated inflammation by driving M2 macrophage polarisation during acute wound healing. GPNMB activity was impaired in the diabetic wound environment with reduced MSC recruitment, and this impairment was reversed by topica…
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