Radiation Mitigating Properties of Intranasally Administered KLSurfactant in a Murine Model of Radiation-Induced Lung Damage.
MouseRadiationC57BL/6Femalen = 15-30 mice per group depending on the assessment time point…Intranasal instillation under light isoflurane anaesthesia, enabling intrapulmonary deliveryApproximately 120 mg/kg total phospholipid per dose, given…Beginning 24 hours after irradiation
Model: Single 13.5 Gy targeted thoracic X-irradiation delivered on the Small Animal Radiation Research Platform via a single anterior-posterior 225 kV beam
KL4 surfactant preserved arterial oxygen saturation at 2, 4 and 18 weeks whereas untreated and vehicle-treated irradiated mice desaturated, lowered BALF white cell counts at the early phase (45 plus or minus 4 versus 64 plus or minus 3 untreated, p=0.018) with undetectable neutrophils at 18 weeks,…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.