Neuroprotective Effects of Valproic Acid in a Rat Model of Cauda Equina Injury.
RatCrushOther / unspecifiedSprague-DawleyMalen = 30 rats randomly allocated to three groups300 mg/kg in salineFirst dose 2 h before surgery, then continued after surgery
Model: Laminectomy at L4 with silicone gel implantation into the epidural space at L5 and L6 producing cauda equina compression
Valproic acid significantly improved lower limb motor function, reduced Wallerian degeneration and demyelinating lesions with increased myelination, and decreased apoptotic neuron counts in the spinal cord anterior horn and dorsal root ganglia relative to saline controls.
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