Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma.

PMID 28850300 ↗2017Reported benefit

Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma.

MouseRadiationB6D2F1/JFemalen = 16 to 20 mice per group at randomisation, 16 to 22 per grou…SubcutaneousPegylated G-CSF 1,000 micrograms/kg in 0.2 ml, equivalent t…First dose 4 h after irradiation alone or combined injury

Model: Whole-body cobalt-60 gamma irradiation at 9.5 Gy delivered at 0.4 Gy/min in a bilateral field, alone or followed within 1 to 2 h by a 15 per cent total body surface area full-thickness skin wound between the scapulae

Combined pegylated G-CSF and Alxn4100TPO raised 30-day survival from 60 to 95 per cent after radiation alone and from 35 to 55 per cent after combined injury, limited body weight loss, reduced acute radiation syndrome and improved haematopoiesis and ileal structure, but did not accelerate wound hea…

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Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma.

Evidence by therapy association

Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma.