Activation of 5-HT Receptors Restores KCC2 Function and Reduces Neuropathic Pain after Spinal Cord Injury.
RatSpinal cord injuryHemisection / partialFemaleAcute administration after establishment of injury-induced hyperalgesia
Model: Thoracic spinal cord hemisection (central neuropathic pain) and spared nerve injury of the sciatic nerve (peripheral neuropathic pain)
TCB-2 reduced mechanical and thermal hyperalgesia after spinal cord injury in association with increased dorsal horn membrane KCC2 expression, and this analgesia was prevented by intrathecal DIOA. The same treatment did not attenuate spared nerve injury-induced neuropathic pain despite a slight inc…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.