Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-kB signalling.
RatSpinal cord injuryCompressionSprague-DawleyFemalen = n = 8 per group for behavioural endpoints and n = 5 per gro…Oral gavage80 mg/kg/day (dissolved in peanut oil); 30 microM in BV-2 c…First dose immediately after injury
Model: Traumatic spinal cord injury by T9 laminectomy and extradural compression with a vascular clip (15 g force) for 1 minute
NBP improved locomotor recovery from day 7 onwards, reduced lesion cavity area, neuronal apoptosis and TUNEL-positive cells, and suppressed microglial activation and TLR4/NF-kB-driven cytokine release both in vivo and in an LPS-stimulated BV-2 and PC12 co-culture.
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