Protective effects of cyclic helix B peptide on aristolochic acid induced acute kidney injury.
MouseChemical/toxinBALB/cMalen = Four treatment groups; group sizes not stated in the abstra…4 nmol/kg and 8 nmol/kg
Model: Acute kidney injury induced by aristolochic acid at 10 mg/kg
CHBP dose-dependently lowered blood urea nitrogen and serum creatinine, improved tubular injury and inflammatory infiltration, reduced apoptotic and active caspase-3 positive cells, inhibited caspase-3 and caspase-9 and increased bcl-2 and bcl-xl expression.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.