Hydroalcoholic extract from bark of Persea major (Meisn.) L.E. Kopp (Lauraceae) exerts antiulcer effects in rodents by the strengthening of the gastric protective factors.
RatChemical/toxinMaleOral (p.o.)30 to 300 mg/kg in acute models; 300 mg/kg in the chronic a…
Model: Ethanol, ethanol/HCl and indomethacin-induced acute gastric ulcer, plus acetic acid-induced chronic gastric ulcer
HEPM at 300 mg/kg orally prevented ethanol-induced and indomethacin-induced gastric lesions by 58.98% and 97.48% respectively versus vehicle (148.00 +/- 14.83 mm and 12.07 +/- 1.61 mm), and reduced chronic acetic acid ulcer area by 40.58% versus vehicle (127.90 +/- 12.04 mm). Healing was confirmed…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.