Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
RatOtherPiebald Virol Glaxo (PVG)Femalen = Three cohorts: cohort 1 n = 30 (10 per group), cohort 2 n =…Lomerizine orally in butter; oxATP and YM872 by subcutaneously implanted mini-osmotic pump (Alzet Model 2002) with cannula targeting the injured dorsal optic nerveLomerizine 30 mg/kg; oxATP 1 mM and YM872 240 micromolar di…Treatment began on the day of surgery after full recovery from anaesthesia
Model: Partial transection of the dorsal right optic nerve approximately 1 mm behind the eye to a controlled depth of 200 micrometres using a diamond radial keratotomy knife, modelling secondary degeneration in ventral optic nerve
Partial optic nerve transection acutely increased Tau phosphorylation and acetylated tubulin and decreased NogoA in ventral nerve vulnerable to secondary degeneration. At day 3 all inhibitor combinations reduced phosphorylated Tau ratios, increased NogoA and shortened the paranodal gap. Only Lomeri…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.