Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis.
MouseChemical/toxinSwiss albinoMalen = 40 mice divided into five groupsAllicin oral; doxorubicin intraperitonealAllicin 10 or 20 mg/kg; doxorubicin given on days 7, 9 and…Allicin given as pretreatment before doxorubicin
Model: Acute doxorubicin-induced cardiotoxicity
Doxorubicin significantly reduced cardiac reduced glutathione and antioxidant enzyme activities and raised nitric oxide, malondialdehyde, cardiac injury biomarkers and proinflammatory cytokines, with necrotic and degenerative histological change and marked myocardial caspase-3 and COX-2 expression.…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.