Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament.
RatWoundWistarMalen = 6 rats total, 3 per treatment group, bilateral MCL transect…Intraperitoneal injection in the lower right quadrant plus topical application to the ligament200 microlitres of 0.5 micrograms per microlitre (100 micro…Immediately following transection
Model: Bilateral full mid-substance transection of the medial collateral ligament in the transverse plane, under isoflurane anaesthesia
IL-17 neutralisation significantly decreased M2 macrophages in the healing region (p = 0.001), increased T cells across the ligament (p = 0.05) and increased IL-2, IL-6 and IL-12 (p = 0.004, 0.014 and 0.03) at 7 days, while IL-10 and IL-1 beta were unchanged. Wound area, wound length, type I procol…
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