Transient Ingrowth of Lymphatic Vessels into the Physiologically Avascular Cornea Regulates Corneal Edema and Transparency.
MouseWoundC57BL/6FemaleIntraperitoneal500 µg per injectionDirectly before surgery, then on days 3, 6, 9 and 12 after surgery
Model: Central perforating corneal incision injury of the right eye made with a surgical blade under ketamine (100 mg/kg) and xylazine (10 mg/kg) anaesthesia
Blockade of lymphangiogenesis with mF4-31C1 reduced the lymphvascularised area (4.86% versus 8.87% at 1 week and 4.93% versus 10.88% at 2 weeks, p < 0.001) and delayed resolution of corneal oedema, with greater central corneal thickness at 3 weeks (110.8 µm versus 100.6 µm, p < 0.05) and 4 weeks (1…
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