PRECLINICAL PUBLICATION · 2018

Neuroprotective Effects of C-terminal Domain of Tetanus Toxin on Rat Brain Against Motorneuron Damages After Experimental Spinal Cord Injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

C-terminal domain of tetanus toxin (Hc-TeTx)

PMID 28767631 ↗2018Reported benefit

Neuroprotective Effects of C-terminal Domain of Tetanus Toxin on Rat Brain Against Motorneuron Damages After Experimental Spinal Cord Injury.

RatSpinal cord injuryUnspecifiedn = 28 adult rats, 7 per group across 4 groups

Model: Experimental traumatic spinal cord injury

Hc-TeTx improved locomotor recovery and motor neuron survival and decreased expression of bax, bad, bak, cleaved caspase-3, Ask1 and the autophagy proteins Atg5 and LC3II in brain.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.