Necrostatin-1 Protects Against D-Galactosamine and Lipopolysaccharide-Induced Hepatic Injury by Preventing TLR4 and RAGE Signaling.
MouseChemical/toxinC57BL/6MaleIntraperitoneal1.8 mg/kg in 2% dimethyl sulfoxide in phosphate-buffered sa…1 hour before D-galactosamine and lipopolysaccharide administration
Model: Fulminant hepatic failure induced by D-galactosamine 800 mg/kg with lipopolysaccharide 40 µg/kg
Necrostatin-1 attenuated the rise in RIP1 and RIP3 expression, phosphorylation and complex formation, markedly reduced mortality and serum alanine aminotransferase, and lowered HMGB1 and interleukin 33 release with reduced pattern recognition receptor signalling.
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