Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model.
RatOtherFisher 344 (Charles River)Femalen = 43 rats euthanised; at least five specimens per treatment g…Surgical implantation through a 0.9 mm bone tunnel in the supraspinatus insertion footprint, anchored to periosteum with 9-0 silk suturesOne construct per operated shoulder; constructs approximate…Acute group repaired immediately at tenectomy; chronic group repaired after 4 w…
Model: Unilateral full-thickness tenectomy of the right supraspinatus tendon from the humerus via transacromial approach; chronic group had the detached tendon end encased in silicone tubing and left retracted for 4 weeks before repair
Construct repair produced no significant difference in stiffness or ultimate load to failure compared with suture repair in either acute or chronic injury, and all repairs remained weaker than contralateral controls. Construct-repaired shoulders failed at the tendon mid-substance rather than the en…
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