Protective Role of Apelin Against Cyclosporine-Induced Renal Tubular Injury in Rats.
RatChemical/toxinMaleSubcutaneous injectionApelin-13 15 micrograms/kg/day; ciclosporin A 15 mg/kg/dayCo-administered with ciclosporin A over the 7-day exposure period
Model: Ciclosporin A (15 mg/kg/day) given subcutaneously for 7 days to induce renal tubular injury without glomerular filtration rate reduction
Ciclosporin A produced increased urinary creatinine excretion, polyuria, renal glycosuria and raised urinary NGAL without reducing glomerular filtration rate. Apelin-13 attenuated the tubular injury and lowered tubulo-interstitial injury scores, with the authors attributing the effect to nitric oxi…
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