Screening for the protective effect target of deproteinized extract of calf blood and its mechanisms in mice with CCl4-induced acute liver injury.
MouseChemical/toxinICR (SPF grade)Malen = n = 10 per group across 4 groups, 40 mice in totalIntragastricDECB 1 g/kg; positive control Hugan tablets 20 mL/kg; norma…Pre-treatment for 30 days before injury, with carbon tetrachloride given 2 hour…
Model: Acute liver injury induced by 10 per cent carbon tetrachloride in blend oil at 10 mL/kg, given 2 hours after the last treatment dose; control animals received blend oil alone
DECB reduced serum ALT (33.01 plus or minus 5.86 versus 56.46 plus or minus 11.30 IU/L) and AST (65.34 plus or minus 15.39 versus 97.73 plus or minus 9.33 IU/L) relative to the model group, lowered MDA and the hepatocyte apoptosis index (2.89 plus or minus 0.55 per cent versus 6.09 plus or minus 0.…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.