The Use of Recombinant nAG Protein in Spinal Cord Crush Injury in a Rat Model.
RatCrushSpinal crushSprague-Dawley (per MeSH indexing)Male (per MeSH indexing)n = 8 rats in total: 4 control and 4 experimentalSingle intra-dural injectionImmediately after the injury
Model: Acute spinal cord crush injury using the aneurysm clip injury model
Weight was maintained in nAG-treated rats but not controls, and from 3 weeks after injury motor recovery was significantly better in the treated group (p less than 0.05). MRI at 6 weeks showed better cord continuity and less fluid accumulation, and histology showed less gliosis, tissue architecture…
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