MicroRNA-155 Inhibition Promoted Wound Healing in Diabetic Rats.
RatWoundSprague-DawleyMaleTopical application to the wound
Model: Cutaneous excisional wound in streptozotocin-induced diabetic rats
Topical miR-155 inhibitor lowered miR-155 expression and accelerated cutaneous wound healing relative to PBS-treated diabetic and normal glucose groups, with fewer neutrophils and macrophages and greater CD31, collagen 1, TGF-beta1 and alpha-SMA.
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