PRECLINICAL PUBLICATION · 2017

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Co-ultramicronised palmitoylethanolamide and luteolin (co-ultraPEALut, 10:1)

PMID 28676456 ↗2017Reported benefit

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury.

MouseOtherC57BL/630 mg/kg

Model: Complete ligation of the left carotid artery for 14 days (neointimal hyperplasia model of vascular injury)

PEA/PLD 30 mg/kg reduced vessel damage, adhesion molecule expression, proinflammatory cytokine production, iNOS and PAR formation, NF-kappaB expression and apoptosis activation after carotid ligation.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.