PRECLINICAL PUBLICATION · 2017

Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Recombinant human Neuregulin-1 beta 1 encapsulated in poly(lactic-co-glycolic acid) (PLGA) microparticles

PMID 28668379 ↗2017Reported benefit

Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleLocal intraspinal injection

Model: Traumatic spinal cord injury

Local intraspinal PLGA-Nrg-1 maintained significantly higher and more prolonged tissue Nrg-1 than intrathecal osmotic pump delivery, preserved oligodendrocytes and axons, and attenuated neuroinflammation and glial scarring.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.