Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis.
MouseRadiationC57BL/6JFemalen = n=18 or 12 per group for Morris water maze, n=12 per group…Tail vein (intravenous) injection0.5 uM antagomir dissolved in 100 ul DEPC waterImmediately after total abdominal irradiation
Model: Total abdominal irradiation with a single 10 Gy dose of gamma rays at 1.0 Gy/min (Gammacell 40 Exactor), causing distant cognitive impairment
Tail vein miR-34a-5p antagomir prevented the irradiation-induced rise in miR-34a-5p in blood and hippocampus, restored hippocampal Bdnf expression and time in the target quadrant, reduced faecal LCN2, and retained the irradiation-shifted gut bacterial composition.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.