Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.
MouseWoundBALB/cMaleTopical application to the wound
Model: Cutaneous excisional skin wound
AGR2 was induced in the migrating epidermal tongue after excision, and topical recombinant AGR2 accelerated wound healing by increasing keratinocyte migration and fibroblast recruitment, with dose-dependent migration in vitro requiring the adhesion domain.
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