3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.

3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.

Model: Lipopolysaccharide-induced acute lung injury in mice

Pretreatment with DBL improved lipopolysaccharide-induced histological injury and reduced lavage cellularity, protein, nitrite and proinflammatory cytokines, lung wet to dry ratio and myeloperoxidase activity, while raising antioxidant enzyme expression.

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