An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway.

An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway.

Model: Thermal burn injury inducing sterile systemic inflammatory response with secondary acute lung injury

AAAG ODN prolonged survival after burn injury, lowered IRF5 expression in injured skin and reduced circulating and cutaneous TNF-alpha and IL-6, with attenuated acute lung injury. Effects were linked to binding of IRF5 and blockade of its nuclear translocation.

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