Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats' tongues.
RatWoundWistarMalen = 15 Wistar rats, 5 per group (control, dexamethasone, copaib…Oral (intragastric gavage)200 mg/kg/day (10% of the 2000 mg/kg limit dose established…First dose 12 h after injury induction
Model: Standardised transfixing (through-and-through) traumatic injury of the anterior tongue, one perforation in each lobe, damaging epithelial, connective and muscle tissue
Copaiba oil-resin reduced the chronic inflammatory infiltrate score (1.2 +/- 0.20 versus 2.0 +/- 0.0 in controls) and significantly lowered CD68-positive macrophage counts (p = 0.0432), with effects comparable to dexamethasone; the reduction in oedema was not statistically significant.
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