Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.
MouseFractureTibiaCD1Malen = n = 10 per group across 4 groupsOral300 mg/kg micronized PEA plus 600 mg/kg ultramicronized PEA…First dose 1 hour after fracture surgery
Model: Closed distal tibia fracture of the right hindlimb with casting for 28 days, a model of complex regional pain syndrome type I
Oral PEA-MPS started 1 h after tibia fracture and continued for 28 days reduced mechanical and thermal nociception and subjective pain, and improved callus formation, bone density and fracture healing. It lowered mast cell density, NGF, TNF-alpha, IL-1beta, nitrotyrosine, PAR and Bax while raising…
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