Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.
MouseTBIControlled cortical impactC57BL/6, wild-type and calpain-1 knockoutMaleSystemic injection1 h or 4 h after controlled cortical impact
Model: Controlled cortical impact
Post-injury systemic NA101 reduced calpain-2 activity, cell death and lesion volume, and improved motor and learning recovery after controlled cortical impact.
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