Dai-Huang-Fu-Zi-Tang alleviates pulmonary and intestinal injury with severe acute pancreatitis via regulating aquaporins in rats.
RatChemical/toxinSprague-DawleyMalen = n = 8 per group in the main experiment (24 rats total); 40…Oral gavage62 mg/kg in the main experiment; 31, 62 and 124 mg/kg teste…First dose at 0 h after induction of severe acute pancreatitis
Model: Severe acute pancreatitis induced by retrograde biliopancreatic duct infusion of 5% sodium taurocholate (0.1 ml/100 g), with secondary lung and intestinal injury
DHFZT reduced lung and intestinal wet/dry ratios and histological injury scores, lowered serum amylase, lipase, endotoxin, TNF-alpha and IL-6 while raising IL-10, and restored AQP1 and AQP5 in lung and AQP1, AQP5 and AQP8 in intestine.
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