Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2.
MouseWoundERE-Luc and MITO-Luc transgenic reporter miceFemalen = n = 4 per group for dose-response, systemic imaging and wou…Local subcutaneous injection into the area surrounding the wound; vehicle corn oil200 microg/kg of 1e or 1f for wound studies; systemic dose-…Immediately after generation of the wound
Model: Full-thickness dorsal skin wound (1 cm incisional wound through skin and panniculus carnosus, and circular full-thickness excisional wound approximately 9 mm diameter)
Compound 1e at 200 microg/kg locally accelerated healing, giving 73 per cent wound area reduction at 72 h versus 60 per cent for 17beta-estradiol and 50 per cent for vehicle, with increased local proliferation, higher granulation histoscore at day 10 and 25 per cent fewer Iba1-positive macrophages.…
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