Smad7 protects against acute kidney injury by rescuing tubular epithelial cells from the G1 cell cycle arrest.
MouseIschaemia-reperfusionRenalSmad7 gene knockout miceLocal delivery into the kidney
Model: Ischaemia/reperfusion-induced acute kidney injury
Smad7 knockout mice developed worse ischaemia/reperfusion acute kidney injury at 48 h with higher serum creatinine and massive tubular necrosis, whereas local renal Smad7 gene restoration protected the kidney and promoted tubular epithelial cell proliferation via a CDK2/cyclin E-dependent release f…
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