Antihyperalgesic effect by herpes vector-mediated knockdown of NaV1.7 sodium channels after skin incision.
MouseWoundBALB/cn = 76 BALB/c mice subdivided into six groupsVector administered before hindpaw skin incision or sham procedure
Model: Lateral hindpaw skin incision (postincisional pain model), with sham procedure controls
The NaV1.7 antisense HSV vector blocked the mechanical, cold and heat hypersensitivity normally seen 24 and 48 h after hindpaw skin incision, supporting NaV1.7 upregulation as a mechanism of postincisional hyperalgesia.
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