Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair.
MixedSpinal cord injuryUnspecifiedSprague-Dawley for the rat studies; dog strain not statedFemaleImplantation into the spinal cord lesion siteAcute phase after complete spinal cord injury
Model: Severe spinal cord injury in rats and acute complete spinal cord injury in dogs
Cetuximab significantly increased neurogenesis at the lesion site in rats, and cetuximab-modified scaffold implantation in dogs produced neuronal regeneration with myelination and synapse formation, reduced chondroitin sulfate proteoglycan deposition and significant locomotor recovery.
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