Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.
RatTBIFluid percussionSprague-Dawley from Charles RiverMalen = n=8 to 10 per group for PDE4B2 flow cytometry; n=10 per gro…Intraperitoneal0.3 mg/kg in a volume of 6 ml/kgFirst dose 30 min after injury
Model: Moderate parasagittal fluid-percussion traumatic brain injury, fluid pulse 14 to 16 ms at 2.0 plus or minus 0.2 atm, through a 4.8 mm craniotomy 3.8 mm posterior to bregma and 2.5 mm lateral to midline over right parietal cortex
A33 reduced microglial activation and neutrophil infiltration, decreased 3-day contusion volume, improved contextual fear conditioning and water maze retention at 24 h post-training, and reduced cortical atrophy and cortical and CA3 neuronal loss, but did not improve sensorimotor asymmetry, working…
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