Microglia Are Irrelevant for Neuronal Degeneration and Axon Regeneration after Acute Injury.
MouseCrushPeripheral-nerve crushC57BL/6Male and female
Model: Optic nerve crush, with lens injury used as a regeneration-enhancing conditioning lesion
PLX5622 eliminated virtually all microglia yet retinal ganglion cell degeneration, regeneration-associated gene induction and axon regeneration were unaffected; only clearance of dead retinal ganglion cells was impaired and astrocyte repopulation delayed, while concurrent microglia and macrophage d…
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