3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours drip infusion reduces noncompressible hemorrhage by 60% in a rat model.
RatHaemorrhage/shockUncontrolledSprague-DawleyMalen = n = 16 per group across five groupsIntravenousBolus 0.7 mL/kg of 3% NaCl with or without ALM; drip 0.5 mL…Bolus 15 minutes after liver resection; drip commenced at 60 minutes
Model: Noncompressible hepatic haemorrhage and shock induced by liver resection in ventilated, instrumented rats with single or double laparotomy
ALM therapy gave 0% mortality (25% with double laparotomy) versus 87.5% with no treatment and 37.5% with saline, raised cardiac output 2.4-fold and reduced bleeding by up to 60% compared with saline and 75% compared with Hextend; Hextend increased mortality and bleeding.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.