miR-146a-5p acts as a negative regulator of TGF-beta signaling in skeletal muscle after acute contusion.
MouseCrushLimb / muscle crushMale
Model: Acute skeletal muscle contusion producing muscle fibrosis
miR-146a-5p was reduced in contused muscle and its overexpression suppressed fibrosis marker expression in vitro and in vivo, an effect blocked by Smad4 overexpression, indicating an antifibrotic role within TGF-beta signalling.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.