Studies on curative efficacy of monoterpene eugenol on anti-leukemic drug arsenic trioxide induced cardiotoxicity.
RatChemical/toxinWistarMale5 mg/kg body weightGiven as combination treatment with arsenic trioxide
Model: Arsenic trioxide-induced cardiotoxicity, arsenic trioxide 4 mg/kg body weight
Eugenol maintained tissue antioxidant levels and ATPase activity, normalised cytosolic ion levels, reduced membrane peroxidation, restored heart rate and corrected QT prolongation, with histology supporting protection against arsenic-induced oxidative damage.
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