Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 48 rats, 12 per group, with histology and western blot on 5…Intraperitoneal25 mg/kgImmediately before induction of trauma-haemorrhagic shock
Model: Trauma-haemorrhagic shock: bilateral femur fractures with femoral artery haemorrhage to mean arterial pressure below 50 mmHg for 1.5 hours, then resuscitation with lactated Ringer's solution at four times the shed blood volume and 4.5 hours of further anaesthesia
Bruton's tyrosine kinase inhibition with LFM-A13 reduced pulmonary permeability, inflammatory cell influx, circulating cytokines, nitric oxide and inducible nitric oxide synthase, and improved lung histopathology after trauma-haemorrhagic shock.
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